She currently appears in the AMC original television drama series Mad Men as young suburban housewife and mother Betty Draper, but may be best known for her role as Cadence Flaherty in American Wedding (2003), from the American Pie comedy film series.

Jones has also had supporting roles in Anger Management (2003), Love Actually, and Dirty Dancing: Havana Nights. In 2005 she appeared in the film The Three Burials of Melquiades Estrada directed by and starring Tommy Lee Jones. In 2006 in We Are Marshall she played the role of Carol Dawson, wife of coach William ‘Red’ Dawson.

Jones was ranked #82 on the Maxim Hot 100 Women of 2002.